In Situ Gelling System Loaded with Lomefloxacin for Effective Management of Ocular Surface Bacterial Infections
Bhavaya Veer Rastogi
Pharmacy
December 2023
In order to treat bacterial infections on the surface of the eye, this research study looks at the creation and improvement of a novel in situ gelling system for the controlled and prolonged release of the antibiotic memefloxacin, a fluoroquinolone. To expand the bioavailability of mefloxacin hydrochloride, the ongoing work set off to create and survey a polymeric visual in situ gel framework involving in situ polymers that show a reversible fluid gel stage progress. Poloxamer 407 and hydroxyl propyl methyl cellulose are utilized as mucoadhesive polymers in fluctuating proportions to make in situ gels. The medication fixation, clearness, pH, gelation temperature, thickness, antimicrobial movement, sterility testing, and visual eye aggravation test were undeniably surveyed for the in situ gels. The incompatibilities of drugs and polymers were determined using FT-IR spectroscopy. Between 92.04% and 99.33% of the drug was cumulatively released from the formulations at 10 hours, with the drug being released via the diffusion process. The outcomes showed that the concentration of polymers utilised affected the degree of gelation and medication release. It was found that the enhanced plan (PH5) had the ideal pH and gelation temperature required for an in situ gel drug conveyance framework. The consequences of this study are expected to give significant new data to the improvement of refined visual medication conveyance frameworks, giving a practical way to deal with the productive treatment of bacterial diseases of the visual surface.
© Airo Journals 2021
