MECHANISTIC UNDERSTANDINGS AND TREATMENT APPROACHES FOR CANCER THERAPY THAT TARGET ANTI-APOPTOSIS GENES
Om Prakash Kumar
Pharmacy
December 2023
Cancer, a global health issue, may avoid apoptosis. All cancer cells defy apoptosis and divide and proliferate uncontrollably. Every eukaryotic cell undergoes apoptosis, or cell suicide. Damaged DNA activates apoptosis to kill the cell. Apoptosis is a highly ordered process: cellular membranes are ruptured, chromosomes are damaged, DNA fragments, and immune cells cleanly engulf the dying decreasing cell. This review discusses cancer treatment targets based on apoptotic mechanisms. Evasion of apoptosis leads to uncontrolled cell growth and illnesses like cancer. Developing apoptosis-targeted anticancer medicines is popular because apoptosis generates little inflammation. New techniques to trigger apoptosis in cancer cells have been developed as researchers have learned more about apoptosis and how tumor cells employ it to fight cell death. This review examined the mechanism of apoptosis and the dysregulation of death receptors (DRs) proteins, cellular FLICE inhibitory proteins (c-FLIP), anti-apoptotic Bcl-2 proteins, inhibitors of apoptosis proteins (IAPs), and tumor suppressor (p53) in cancer cells, as well as current clinical approaches to selectively induce apoptosis in cancer cells.
© Airo Journals 2021
